Nanosecond Time-resolved Mid-Infrared Transient Absorption Spectrometer

Penn State inventors have developed a novel infrared transient absorption (MIR-TA) spectrometer that has enhanced sensitivity, versatility, and ease of use as compared to current models. Researchers believe that a 100x increase in signal over known methods, coupled with a 10x lower price point than conventional instruments, will allow for new market opportunities and enable researchers to use MIR-TA to characterize chemical processes, catalysis, and biochemical reactions.

3’-deoxy-3’,4’-didehydro-cytidine triphosphate (ddhCTP): A Novel Broad Spectrum Viral Inhibitor

Inventors from Penn State and Yeshiva University have developed novel therapeutic composition-of-matter that can be used to treat flavivirus infections. Due to their unique mechanism of action, these potential therapeutics may also have activity as broad spectrum antivirals, and could be used to treat both DNA and RNA viruses.

Versatile Display Scaffolds for Proteins

Advances in cryo-EM software, hardware, instrumentation, and data collection have largely been restricted to proteins and complexes that are large (>200kD), hydrophilic, and often symmetrical. To overcome these limitations, Penn State inventors have developed a versatile molecular platform that can enable cryo-EM approaches for previously poorly-behaved specimens, including small proteins and therapeutic small molecules, further streamlining sample preparation and allowing for easy plug-and-play deployment.

Viable and Non-Photobleaching Cellular Labeling Technique Using Light-Emitting Transition Metal Dichalcogenide Monolayers

Penn State inventors have developed an atomically-thin material with strong light-emitting properties and accompanying methods to label and image living organisms including cancer cells, bacteria, and viruses. The inventors believe that this material,  through its resistance to photo-bleaching and ability to pass from progenitor to daughter cells/viral particles, opens a door to develop the next generation of cellular imaging and labeling approaches, from monitoring transmissions of infectious diseases to imaging cancer metastasis.

IDEAS: an Integrative and Discriminative Epigenome Annotation System

Penn State inventors have developed novel statistical methods that utilize genomic data to predict the gene(s) and cell type(s) affected by disease-related genetic variants. Proof-of-concept results demonstrate that, for complex human diseases, the invention is able to significantly narrow down the list of likely causal disease variants and affected cell types, allowing for efficient confirmation via in vitro methods.

Inhalable Antimicrobial Peptide Particles

Penn State inventors have developed a novel class of inhalable antibiotic-loaded microgel particles to address the urgent need for new therapeutic strategies that can effectively treat resistant tuberculosis (TB) and reduce the frequency of dosing. Meant to enhance the therapeutic utility of both traditional antibiotics and investigational compounds, this low-cost and biocompatible delivery platform could be readily integrated into existing treatment programs and drug discovery campaigns.

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