Flexible 3D Printing

Development of a printer that can produce rubber- or silicone-like materials with high elasticity, high temperature tolerance, and high chemical resistance for additive manufacturing using a blend of a blend of nanoparticulate photothermal agents and pre-polymer mixtures that absorb light and convert the absorbed light to heat, instantly curing.

Ben Lear, 2018 LB2C Recipient

 

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Nanosecond Time-resolved Mid-Infrared Transient Absorption Spectrometer

Penn State inventors have developed a novel infrared transient absorption (MIR-TA) spectrometer that has enhanced sensitivity, versatility, and ease of use as compared to current models. Researchers believe that a 100x increase in signal over known methods, coupled with a 10x lower price point than conventional instruments, will allow for new market opportunities and enable researchers to use MIR-TA to characterize chemical processes, catalysis, and biochemical reactions.

John Asbury, 2017 LB2C Recipient

 

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IDEAS: Integrative and Discriminative Epigenome Annotation System

Penn State inventors have developed novel statistical methods that utilize genomic data to predict the gene(s) and cell type(s) affected by disease-related genetic variants; the invention is able to significantly narrow down the list of likely causal disease variants and affected cell types, allowing for efficient confirmation via in vitro methods.

Shawn Mahony (Yu Zhang, 2017 LB2C Recipient)

 

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AggGlow - Early Visualization of Neurodegeneration

First product able to detect misfolded proteins in live cells using small molecule fluorophores to quantify pre-fibril protein oligomers and insoluble protein aggregates in vitro and in vivo. AGlow kit will open new market opportunities by enabling researchers to determine how misfolded proteins contribute to disease, develop tools to diagnose associated diseases at a pre-symptomatic stage, and develop screens to generate novel therapeutic leads.

Xin Zhang, 2018 LB2C Recipient

 

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CryoEM: Versatile Display Scaffolds for Proteins

Penn State inventors have developed a versatile molecular platform that can enable cryo-EM approaches for previously poorly-behaved specimens, including small proteins and therapeutic small molecules (<200kD), further streamlining sample preparation and allowing for easy plug-and-play deployment.

Susan Hafenstein & Scott Lindner, 2017 LB2C Recipient

 

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Virus Diagnostic Device

The research team developed and tested a small, portable device that increases the sensitivity of virus detection by trapping and concentrating viruses in an array of carbon nanotubes.

Mauricio Terrones, 2015 & 2016 LB2C Recipient

 

ECOS Startup – Virolock
New Antibiotics: Inhibitors of Bacterial Stress Pathways

Penn State inventors have identified a novel therapeutic target, transcription factor σE, which is conserved in several multidrug resistant Gram-negative pathogens and are currently pursuing the development and validation of initial lead compounds.

Ken Keiler, 2018 LB2C Recipient

 

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Lectins as Anti-Cancer Therapeutics

Novel lectins were discovered from plant root transcriptome samples and found to inhibit certain fungi and has potent anti-cancer activity against five types of epithelial cancers at picomolar concentrations.

Jim Marden & Scott Medina, 2017 LB2C Recipient

 

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Optimizing & Controlling Co-Translational Protein Folding

Computer simulations that model the mechanics of protein translation to pinpoint how translation rate affects protein malfunctions and promises to be key to understanding several diseases, including cystic fibrosis and some varieties of lung, cervical and vulvar cancer.

Edward O’Brien

 

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